The dictionary definition is:
verb:
1.to fit badly.
noun:
2.something that fits badly, as a garment that is too large or too small.
3.a person who is not suited or is unable to adjust to the circumstances of his or her particular situation:
a misfit in one’s job.
In all (3) cases, it is not positive.
I would prefer it meant: to not fit the norm. Or, to think outside the box.